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Pharma
Zephex® - A leader in medical propellants
As a world leader in the manufacture and supply of very high purity HFA medical propellants, Orbia Fluor & Energy Materials produces to the most demanding industry standards at dedicated facilities. Zephex® medical propellants are used in over two thirds of the world’s metered dose inhalers (MDIs).
This commitment to the highest levels of medical propellant quality is supported by a detailed understanding of customer needs and backed by the support of our experienced teams with many years of technical expertise.
We’re proud to support 100 million patients in accessing life-saving medication every year.
Zephex® medical propellants
Zephex® 152a
A sustainable, low-GWP medical propellant that has been developed by Orbia Fluor & Energy Materials over several years; Zephex® 152a is for use in metered dose inhalers (MDIs) for treatment of respiratory disorders such as asthma and COPD.
Zephex® 134a
Relied upon by leading organizations within the MDI space for over thirty years, Zephex® 134a is by far the most widely used medical propellant in the world.
Zephex® 227ea
Produced to our exacting, industry-leading standards, Zephex® 227ea offers performance characteristics complementary to Zephex® 134a.
The transition to low-GWP propellant solutions
The low-GWP transition
In supporting our industry partners, we’re helping the industry navigate the F-Gas regulations throughout the transition to low-GWP propellants.
Continued supply of Zephex® 134a in line with market needs
We're dedicated to protecting the continuation of supply of Zephex® 134a throughout the low-GWP transition; ensuring patients worldwide retain access to lifesaving medicine.
Formulation and lab services
We are more than just our medical propellant. We are a supporting partner to the industry, helping with formulation services, support on the low-GWP transition and via our extensive lab services.
Our formulation services are designed to support early-stage development studies specialising in HFA-152a with internal capability to formulate and test pMDI products at bench and pilot (5L) scale.
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Technology centers
Orbia Fluor & Energy Materials operates Technology Centers within key regions to enable R&D excellence across its business units.
Within the Pharma Business Unit, our Cheshire (UK) technology center serves as the key technology hub, positioned as our core medical propellants applications lab. It’s home to R&D specialists and technical experts bringing the low-GWP transition to life.
Quality and regulatory
Zephex® propellants are manufactured at our industry leading facilities where all products are subject to a comprehensive quality control processes involving eleven separate tests to confirm purity and quality.
Dedicated stainless steel containers are used for the supply of Zephex® at manufacturing scale, eliminating problems associated with conventional packaging common to the rest of the industry. A number of steps are taken to ensure the quality of each package we supply, including security tagging with a unique number recorded on the Certificate of Analysis. This certificate contains a hologram mark to assure customers they are receiving only pure Zephex® quality.
Orbia Fluor & Energy Materials´ detailed understanding of the needs, standards and regulatory requirements of our pharmaceutical customers combined with expertise in fluorine chemistry and chemical handling makes us unique in the manufacture of propellants for pharmaceutical uses.
Terms and conditions of sale
Here you’ll find further information on our terms and conditions of sale associated with our Pharma business unit.
Zephex® – Channelling over 30 years of experience into the future of medical propellants in MDIs
Speak with one of our experts
Do you have a question regarding medical propellants for one of our experts?
Document downloads
Here you can download additional support materials for our medical propellants and other informative resources such as flyers, white papers and guides.